Thursday, September 2, 2010 8:00 PDT - USC vs Hawaii.
at 
Complete USC 2010 Football Schedule
| 2010 SCHEDULE |
| Date | Opponent / Event | Location | Time / Result |
| 09/02/10 | at Hawai'i  |
Honolulu, Hawaii | 8:00 p.m. PT |
| 09/11/10 | vs. Virginia |
L.A. Coliseum | 7:30 p.m. PT |
| 09/18/10 | at Minnesota |
Minneapolis, Minn. | 12:30 p.m. PT |
| 09/25/10 | at Washington State * | Pullman, Wash. | TBA |
| 10/02/10 | vs. Washington * |
L.A. Coliseum | 5:00 p.m. PT |
| 10/09/10 | at Stanford * |
Palo Alto, Calif. | 5:00 p.m. PT |
| 10/16/10 | vs. California * |
L.A. Coliseum | 12:30 p.m. PT |
| 10/30/10 | vs. Oregon * |
L.A. Coliseum | 5:00 p.m. PT |
| 11/06/10 | vs. Arizona State * | L.A. Coliseum | TBA |
| 11/13/10 | at Arizona * |
Tucson, Ariz. | 5:00 p.m. PT |
| 11/20/10 | at Oregon State * |
Corvallis, Ore. | 5:00 p.m. PT |
| 11/27/10 | vs. Notre Dame |
L.A. Coliseum | 5:00 p.m. PT |
| 12/04/10 | at UCLA * | Rose Bowl | TBA |